Fig 3. The Malaria Box compounds’ estimated hydrophobicity (clogP) is not correlated with lipid bilayer effects.

Plot of the quench rate (relative to control) vs. cLogP, which was calculated using the ALOGP algorithm [44] as implemented by Collaborative Drug Discovery, Inc. (http://collaborativedrug.com, Burlingame, CA). MMV007384 (red dot cLogP = 6.37); from L to R (amber dots): MMV020548, cLogP = 3.39; MMV020549, cLogP = 4.16; and MMV019258, cLogP = 4.01.