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. Author manuscript; available in PMC: 2016 Nov 5.
Published in final edited form as: Cell. 2015 Nov 5;163(4):811–828. doi: 10.1016/j.cell.2015.10.044

Figure 2.

Figure 2

Regulation of the Hippo pathway in Drosophila. The Hippo pathway is regulated by cell adhesion molecules (Ed), determinants of cell polarity (Crb, Fat/Ds, Scrib complex), and mechanical cues (spectrin, F-actin, or cellular tension). In addition, Hpo is regulated by Tao, salt induced kinase (Sik), Ras-associated factor (Rassf), striatin-interacting phosphatase and kinase (STRIPAK) complex; Wts is regulated by Zyxin (Zyx) and Jub; Yki is regulated by WW Domain Binding Protein 2 (Wbp2), Hipk, and Multiple ankyrin repeats single KH domain (Mask) (refer to (Varelas, 2014)). Arrows, blunt ends, and dashed lines indicate activation, inhibition, and indirect regulation, respectively.