Table 1.
Murine genetic tools for analysis of fibrotic cell types.
| Cell Type | Driver | Use | Organ | Reference |
|---|---|---|---|---|
| Dermal fibroblast | Dik1 | • Lineage tracing | • Dorsal dermis | (8) |
| Lrig1 | • Lineage tracing | • Dorsal dermis | (8) | |
| Blimp1 | • Lineage tracing | • Dorsal dermis | (8) | |
| PDGFRα | • Genetic reporter | • Dorsal dermis | (8) | |
| Engrailed -1 | • Lineage tracing • Ablation |
• Dorsal dermis | (9) | |
| Oral fibroblast | Wnt1 | • Lineage tracing • Ablation |
• Oral dermis | (9) |
| Interstitial fibroblast | Myelin protein zero (P0) | • Lineage tracing • Genetic reporter |
• Kidney | (10) |
| Fibrocyte | Vav1 | • Conditional knock out of Col1a1 | • Hematopoietic cells | (11) |
| Pericyte | ADAM12 | • Lineage tracing • Ablation • Genetic Reporter |
• Ear dermis • Skeletal muscle |
(12) |
| Glast1 | • Lineage tracing • Blocking cell proliferation |
• Spinal cord | (13) | |
| Nestin | • Lineage tracing • Genetic reporter |
• Spinal cord • Brain • Lung • Kidney • Heart • White adipose tissue |
(14,15) | |
| NG2 (Cspg4) | • Genetic reporter • Ablation |
• Spinal cord • Brain • Lung • Kidney • Heart |
(14,16) | |
| αSMA (Acta2) | • Lineage tracing • Genetic reporter • Conditional knock out of TGFβR2 |
• Kidney | (16) | |
| FoxD1 | • Lineage tracing • Genetic reporter |
• Kidney • Lung |
(17,18) | |
| PDGFRβ | • Genetic reporter • Ablation • Conditional knock out of αv integrin |
• Kidney • Lung |
(16,19) | |
| Gli1 | • Lineage tracing • Ablation |
• Heart • Kidney • Liver • Lung |
(20) | |
| Col1a1 | • Lineage tracing • Genetic reporter |
• Kidney • Liver • Dermis • Skeletal muscle |
(21,22,23,24,25) | |
| Adipocyte | Adiponectin | • Lineage tracing | • Dorsal dermis | (26) |
| Hepatic stellate cell | Lrat | • Genetic reporter | • Liver | (27) |
| Epithelial cell | Albumin | • Lineage tracing | • Liver | (23,28) |
| Alfp | • Lineage tracing | • Liver | (29) | |
| γGT | • Lineage tracing | • Kidney | (16,30) | |
| FSP-1 | • Genetic reporter | • Kidney | (30) | |
| Six2 | • Lineage tracing | • Kidney | (17) | |
| HoxB7 | • Lineage tracing | • Kidney | (17) | |
| Sftpc | • Lineage tracing | • Lung | (31) | |
| Scgbla1 | • Lineage tracing | • Lung | (31) | |
| Endothelial cell | VECadherin (Cdh5) | • Lineage tracing | • Kidney • Skeletal muscle |
(16,32) |
| Tie2 | • Lineage tracing | • Kidney • Lung • Skeletal muscle |
(32,33,34) | |
| Tie1 | • Lineage tracing | • Heart | (35) |