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. 2014 Oct 17;10(11):870–874. doi: 10.1038/nchembio.1671

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© Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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(a) Scheme summarizing the mechanism of activation of Nedd8 (yellow) by NAE and inhibition by MLN4924 (red). (b) Structure of adduct between Nedd8 and MLN4924 (derived from Protein Data Bank (PDB) code 3GZN⁶). Nedd8 is shown in yellow and MLN4924 in red. (c) Structure of Nedd8-MLN4924 bound to NAE (tan; PDB code 3GZN⁶).