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Published in final edited form as: Trends Genet. 2014 Mar 11;30(4):124–132. doi: 10.1016/j.tig.2014.02.003

(a) The number of low frequency variants required to explain the remaining missing heritability for human height and (b) the power to detect variants that underlie complex common disease with 10,000 cases and 10,000 matched controls. For (a) the heritability remaining $h_{r}^{2}$ for human height that is not explained by associations with common SNPs was taken to be 30% and the number of variants was estimated by $\frac{h_{r}^{2}}{2 p (1 - p) a^{2}}$ , where a is the effect size in SD (0.15, 0.25, 0.5, or 1) and p is the minor allele frequency of the causal variants. For (b) the power to detect variants for complex diseases of different prevalence with 10,000 cases and 10,000 matched controls.

(a) The number of low frequency variants required to explain the remaining missing heritability for human height and (b) the power to detect variants that underlie complex common disease with 10,000 cases and 10,000 matched controls. For (a) the heritability remaining $h_{r}^{2}$ for human height that is not explained by associations with common SNPs was taken to be 30% and the number of variants was estimated by $\frac{h_{r}^{2}}{2 p (1 - p) a^{2}}$ , where a is the effect size in SD (0.15, 0.25, 0.5, or 1) and p is the minor allele frequency of the causal variants. For (b) the power to detect variants for complex diseases of different prevalence with 10,000 cases and 10,000 matched controls.