Table 2.

Univariate and multivariate Cox regression analyses of prognostic factors on disease-specific survival of 286 patients who underwent cystectomy for bladder cancer

Parameters	Univariate analysis			Multivariate analysis
	HR	95% Cl	p value	HR	95% Cl	p value
Age
<70*
≥70	1.648	1.047–2.594	0.028	1.630	1.092–2.608	0.042
Gender
Female
Male	1.322	0.832–2.026	0,736
Lymph node invasion
Negative*
Positive	3.940	2.623–5.919	<0.001	1.517	1.097–2.370	0.030
Pathological stage
T2≤*
T2>	7.114	4.716–10.730	<0.001	5.463	3.469–8.606	<0.001
Histologic type
Urothelial carcinoma
Non-urothelial carcinoma	2.116	1.428–3.136	<0.001	1.533	1.020–2.305	0.040
Surgical margin
Negative*
Positive	1.852	1.062–3.231	0,026
Grade
Low*
High	4.741	2.864–7.848	<0.001	3.337	1.993–5.587	<0.001
Lymphovascular invasion
Negative*
Positive	2.690	1.840–3.934	<0.001
Carcinoma in-situ
Positive*
Negative	1.164	0.920–1.487	0,125
Preoperative hydronephrosis
Negative*
Positive	2.359	1.637–3.398	<0.001
Leukocyte
≤11 000*
>11 000	2.086	1.314–3.310	0.002	1.773	1.096–2.687	0.020
Neutrophil
<7700*
≥7700	1.528	1.023–2.283	0.035
Lymphocyte >1500
Lymphocyte ≤1500	1.435	0.816–2.532	0.691
NLR
<2.5*
≥2.5	1.798	1.260–2.567	0.001	1.965	1.042–3.586	0.022

CI: Confidence interval; HR: hazard ratio;

^*Reference category; NLR: neutrophil-to-lymphocyte ratio.