Table 2.

Test characteristics of sepsis screening tests.

Test	Algorithmic Alert	Physician Judgment	Combined Method	Sequential Method
	Test Characteristic (95% CI)
Sensitivity	92.1 (91.67–92.43)	72.73 (72.1–73.35)	96.6 (96.3–96.9)	68.2 (67.5–68.8)
Specificity	83.4 (82.91–83.95)	99.51 (99.41–99.61)	83.3 (82.8–83.8)	99.6 (99.6–99.7)
Positive predictive value	2.5 (2.24–2.67)	40.25 (39.56–40.94)	2.6 (2.3–2.8)	47.6 (46.9–48.3)
Negative predictive value	99.96 (99.93–99.99)	99.88 (99.83–99.93)	99.98 (99.96–100)	99.86 (99.80–99.91)
Positive likelihood ratio	5.6 (5.18–5.95)	148.79 (117.2–1900)	5.8 (5.5–6.1)	200.8 (151.8–266.7)
Negative likelihood ratio	0.09 (0.05–0.19)	0.27 (0.19–0.39)	0.04 (0.01–0.12)	0.32 (0.24–0.43)
Receiver operative characteristic curve area	0.88 (0.85–0.91)	0.86 (0.81–0.91)	0.90 (0.88–0.92)	0.84 (0.79–0.89)

Severe sepsis/septic shock prevalence: 88 (0.45%)