Table 4.

a. Algorithmic alert and physician judgment test characteristics across age strata.

b. Algorithmic alert and physician judgment test characteristics in subjects with at least one comorbidity.

a.
Method	Age Category	Positive Test n (%)	Severe Sepsis n (%)	Sensitivity	Specificity	Area under ROC curve
				Test Characteristic (95% CI)
Algorithmic alert	57 days to <1 year (n=4,411)	203 (4.6)	7 (0.2)	85.7 (84.7–86.8)	95.5 (94.9–96.1)	0.95 (0.88–1.0)
	1 year to <4 years (n=9,480)	1,543 (16.3)	19 (0.2)	79.0 (78.1–79.8)	83.6 (83.0–84.6)	0.85 (0.79–0.91)
	4 years to <13 years (n=4,885)	1,043 (21.4)	41(0.8)	97.6 (97.1–98.0)	79.1 (78.0–80.2)	0.89 (0.87–0.90)
	≥ 13 years (n=748)	502 (67.1)	21(2.8)	95.2 (93.7–96.8)	33.7 (30.3–37.1)	0.65 (0.62–0.68)
Physician judgment	57 days to <1 year (n=4,411)	32 (0.7)	7 (0.2)	85.7 (84.7–86.8)	99.4 (99.2–99.6)	0.92 (0.79–1.0)
	1 year to <4 years (n=9,480)	35 (0.4)	19 (0.2)	63.2 (62.2–64.1)	99.8 (99.7–99.9)	0.81 (0.70–0.93)
	4 years to <13 years (n=4,885)	65 (1.3)	41 (0.8)	75.6 (74.4–76.8)	99.3 (99.1–99.5)	0.87 (0.81–0.94)
	≥ 13 years (n=748)	27 (3.6)	21 (2.8)	71.4 (68.2–74.7)	98.4 (97.4–99.3)	0.85 (0.75–0.95)

b.
Method	Comorbid Condition	Positive Test n (%)	Severe Sepsis n (%)	Sensitivity	Specificity	Area under ROC curve
				Test Characteristic (95% CI)
Algorithmic alert	0 comorbid conditions (n=16,311)	2,030 (12.4)	45 (0.3)	88.9 (88.4–89.4)	87.8 (87.2–88.3)	0.9 (0.87–0.93)
	At least 1 comorbid condition (n=3,213)	1,271 (39.6)	41 (1.3)	95.4 (94.6–96.1)	61.2 (59.5–62.9)	0.79 (0.77–0.81)
Physician judgment	0 comorbid conditions (n=16,311)	91 (2.7)	45 (0.3)	73.3 (72.7–74.0)	99.6 (99.6–99.7)	0.86 (0.80–0.93)
	At least 1 comorbid condition (n=3,213)	68 (2.1)	41 (1.3)	72.1 (70.1–73.6)	98.8 (98.5–99.2)	0.85 (0.79–0.92)