Table 3.

Parameter estimates of time trade-off utilities (mixed effects model) including statistically significant health states and sample variables in the overall multivariable model

Parameter	Parameter estimate	Standard error	P-value	95% confidence intervals
Intercept	1.548	0.177	0.000	1.2, 1.9
Treatment response health states
Stable/no response
Response (partial/complete)	0.406	0.139	0.004	0.13, 0.68
Progressive disease	−1.845	0.139	0.000	−2.12, −1.57
Stable treatment response + AE health states
AE: diarrhea	−2.325	0.139	0.000	−2.6, −2.05
AE: fatigue	−0.576	0.139	0.000	−0.85, −0.30
AE: HFS	−1.793	0.139	0.000	−2.07, −1.52
AE: alopecia	−0.356	0.139	0.011	−0.63, −0.08
EQ-5D-3L
EQ-5D: any usual activity problems	−0.871	0.403	0.031	−1.66, −0.08
EQ-5D: any anxiety/depression problems	1.238	0.465	0.008	0.33, 2.15
Qualifications
Left school at 18 with qualifications or technical/vocational qualifications	0.470	0.254	0.064	−0.33, 0.97
Left school at 16 with qualifications or no formal qualifications	0.861	0.335	0.010	0.20, 1.52

Abbreviations: AE, adverse event; HFS, hand and foot syndrome.