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. 2015 Nov 10;6:271. doi: 10.3389/fphar.2015.00271

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Copyright © 2015 Van Gool, Dedieu, Emonard and Roebroek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of LRP1-mediated tumor growth and metastasis fine tuning. (A) LRP1 clears various cancer-related ligands from the ECM by endocytosis. (B) The LRP1 ICD also interacts with several adaptor and scaffolding proteins. (C) LRP1 expression levels vary among different tumor types and tumor stages and (D) the receptor can undergo shedding and subsequent release of the ICD. (E) Heparanase-1 activation is affected by LRP1-mediated uptake of its inactive precursor. (F) The formation of co-receptor complexes with LRP1 influences signaling and (G) also the phosphorylation of the LRP1 ICD influences signaling and regulates endocytosis. (H) LRP1-mediated signaling affects several well-known pathways linked to cancer.