Skip to main content
. 2015 Nov 10;6:271. doi: 10.3389/fphar.2015.00271

FIGURE 2.

FIGURE 2

Potential clinical applications of LRP1. (A) Using LRP1 as a cargo receptor to sluice chemotherapeutic agents through the tightly controlled blood–brain barrier via transcytosis is undergoing clinical testing. (B) LRP1 antagonists to the ECD could prevent LRP1 internalization and catabolization. (C) The ECD of LRP1 could also be used as a soluble decoy receptor to capture LRP1 ligands and avoid ligand-receptor interaction.