Figure 1.

Pathways leading to ventilation-induced brain inflammation and injury. The pathways involved in the progression of brain injury following high V _T ventilation in the delivery room. High V _T ventilation can lead to cardiopulmonary hemodynamic instability leading to variable and fluctuating carotid blood flow while also instigating an inflammatory response in the lungs, which can migrate systemically. Both pathways can occur independently or together to increase the risk and severity of cerebral white matter injury.