Table 2.

Clinical and laboratory toxicity.

	Placebo period (D1–D2)			Single-dose period (D15–D16)			Repeated-dose period (D22–D30)
	n	(%)	e	n	(%)	e	n	(%)	e
Dry pharynx							4	36	7
Sore throat							8	73	22
Throat burning							4	36	12
Headache							5	45	8
Jaw pain							1	9	1
Neck pain							2	18	3
Dizziness				3	27	3	2	18	5
Poor sleep							4	36	4
Palpitation							2	18	2
Chest stuffiness							3	27	5
Fatigue							1	9	1
Nausea				1	9	1
Skin needling sensation							3	27	3
Skin burning sensation							3	27	8
Limb numbness							4	36	9
Limb pain							1	9	1
Thirsty							1	9	1
ALT							4	36	8
AST							4	36	8

n, Number of subjects; e, number of adverse events; %, proportion of subjects having the event.