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. 2015 Nov 10;9:138. doi: 10.3389/fncom.2015.00138

Figure 1.

Figure 1

Intrinsic timescale of Hebbian learning. (A) The classical STDP pairing protocols widely used in the literature. (B) Synaptic modification for one pair of pre- and post-synaptic spikes, as a function of their relative timing. (C) Evolution as a function of time of a single synaptic weight, after an STDP protocol, for various papers taken from the literature, both for LTP of LTD protocols [dash-dotted thin black line is the null-line for Sjöström et al. (2001)]. (D) Adapted from Keck et al. (2013), Normalized mEPSC amplitude in a layer 5 cell in the mice visual cortex following a lesion in the retina. (E) Adapted from Huang et al. (1992), Prior synaptic activity triggered during the red shaded area (LTP priming, red curve) reduces LTP in CA1 hippocampus compared to control without pre-activation (black curve). (F) Adapted from Mockett et al. (2002), Low frequency stimulation (LFS, red shaded areas) influences non-linearly the amount of LTD in CA1 hippocampus: black curve, (control with only one LFS), red curve (two consecutive LFS).