Figure 1.

The effect of post-weaning social isolation on behavior. (A) Experimental timeline of social isolation and sampling for four experiments. (B) Total distance traveled in an open field test (OFT) in the light (CT8–10) and dark (CT15–18) phases in control and socially isolated rats (light-phase control: n = 11, light phase isolated: n = 12, dark-phase control: n = 9, dark-phase isolated: n = 13). (C) Total time spent in the center during the OFT (s) in the light and dark phases in control and socially isolated rats. (D) Time spent immobile during a forced-swim test for 7 min (control: n = 9 and isolated: n = 17). (E) Comparison of sucrose preference was expressed as a percentage of consumption in control (n = 14) and isolated (n = 17) rats. Data are presented as mean ± SEM for each set. *p < 0.05 and **p < 0.01.