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. 2015 Nov 10;5:16404. doi: 10.1038/srep16404

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Copyright © 2015, Macmillan Publishers Limited

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Statistical parametric mapping (SPM) results are displayed for ADAD mutation carriers (n = 7). Each pair of columns represents an individual mutation carrier compared to five age-matched non-carriers. Each pair of rows represents a different PET biomarker. The scale from left to right represents the approximate time (in years) to the expected onset of clinical symptoms. All SPM clusters shown are significant at p < 0.001 (uncorrected). The figure demonstrates the progressive and heterogeneous nature of Alzheimer’s disease pathology as the expected onset of clinical symptoms approaches; neocortical fibrillar Aβ increases (PIB retention, top two rows), astrocytosis decreases (DED binding, middle two rows), glucose metabolism decreases (FDG hypometabolism shown, bottom two rows).