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. 2015 Nov 10;5:16422. doi: 10.1038/srep16422

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(A,B) miR-23a is elevated in the cell nuclei. Cardiomyocytes were treated with 100 μM hydrogen peroxide (A) or 1 μM doxorubicin (B), and harvested at the indicated time for the isolation cell nuclei. miR-23a was analyzed by qRT-PCR. *p < 0.05 vs control. (C). miR-23a binds to p53. Cells were treated with 100 μM hydrogen peroxide or 1 μM doxorubicin. Cell nuclei were prepared, and immunoprecipitation was performed with the anti-p53 antibody. miR-23a was analyzed by qRT-PCR. *p < 0.05 vs control. (D) p53 and miR-23a association is specific. miR-23a, miR-17 or miR-365 were analyzed in the immunoprecipitates of p53 by qRT-PCR.