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. 2015 Nov 10;5:16422. doi: 10.1038/srep16422

Figure 3. miR-23a can promote the apoptotic effect of p53.

Figure 3

(A) miR-23a overexpression sensitizes p53 to induce apoptosis. The cells were infected with adenoviral p53 at a moi of 5, and then transfected with miR-23a mimics or its control (miR-23a control). Apoptosis was analyzed with the TUNEL assay. *p < 0.05 vs p53 alone. (B) Knockdown of miR-23a reduces apoptosis induced by p53. The cells were transfected with miR-23a antagomir or antagomir negative control (miR-23a NC), and then infected with adenoviral p53 at a moi of 60. Apoptosis was analyzed with the TUNEL assay 48 hours after infection. *p < 0.05 vs p53 alone.