Table 2. A table showing the compressibility of the powders as analysed through out-of-die and in-die Heckel Analysis, with yield pressures giving an indication to the compression mechanism of the powder bed.
| Powder | Out-of-die Yield Pressure (MPa) | In-Die Yield Pressure (MPa) | Disintegration Time (s) |
Hardness (N) |
||
|---|---|---|---|---|---|---|
| 75 MPa | 225 MPa | 75 MPa | 225 MPa | |||
| F0 | 3333.33 | 144.47 ± 8.02 | 35.67 ± 2.08 | 280.00 ± 8.54 | 45.70 ± 5.61 | 120.47 ± 6.59 |
| F1 | 1250.00 | 156.19 ± 17.35 | 52.33 ± 4.16 | 133.00 ± 6.08* | 63.40 ± 10.13 | 161.80 ± 17.41 |
| F2 | 714.29 | 280.88 ± 15.07* | 34.33 ± 2.08 | 125.33 ± 7.51* | 52.03 ± 8.79 | 148.83 ± 5.69 |
| F3 | 833.33 | 380.37 ± 38.95* | 283.00 ± 8.00* | 281.67 ± 6.03 | 113.00 ± 18.49* | 320.53 ± 45.76* |
| F4 | 1666.67 | 229.62 ± 15.20* | 126.67 ± 37.90* | 190.67 ± 13.61* | 93.27 ± 10.17* | 243.00 ± 13.95* |
| F5 | 1666.67 | 240.10 ± 31.98* | 35.33 ± 2.89 | 119.00 ± 6.24* | 51.13 ± 2.32 | 155.93 ± 11.16 |
| F6 | 1250.00 | 324.26 ± 17.44* | 36.67 ± 2.08 | 128.67 ± 3.51* | 47.20 ± 6.68 | 142.53 ± 7.91 |
| F7 | 1250.00 | 202.85 ± 43.75 | 154.67 ± 10.07* | 249.67 ± 6.81 | 107.10 ± 11.44* | 238.10 ± 24.21* |
| F8 | 1250.00 | 226.85 ± 43.21* | 57.67 ± 4.73 | 169.67 ± 23.59* | 87.80 ± 0.70* | 181.93 ± 44.00 |
Also displayed are the hardness and disintegration time of ODTs manufactured from milled mannitol powders (F1-F8) compared to the control (F0) at compression forces of 75 and 225 MPa. Data marked with a single asterisk (*) indicates results that are significantly different from the control (ANOVA p < 0.05 when compared to F0).