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. 2015 Nov 10;5:15928. doi: 10.1038/srep15928

Figure 4. Characterization of the receptor binding specificity of recombinant H9N2 AIVs possessing HA amino acid substitutions identified in adapted viruses.

Figure 4

Recombinant viruses incorporating the indicated amino acid substitution(s) in the background of SD2/H9N2 were generated by reverse genetics and assessed for binding to an α2,6-linked SA (red lines) and α2,3-linked SA (blue lines) glyocpolymer in a solid phase binding assay. Recombinant viruses used include r-SD2 (a), r-SD2/HA1-Q227P (b), r-SD2/HA2-D46E (c), and r-SD2/HA1-Q227P/HA2-D46E (d).