. 2015 Nov 10;5:15928. doi: 10.1038/srep15928

Table 1. Pathogenicity, receptor binding preference and transmissibility of wild-type H9N2 AIVs.

Virus (aberration)	MLD₅₀^a	Receptor binding specificity^b		HA 226 residue^c	Transmission^d
Virus (aberration)	MLD₅₀^a	0.5% CRBCs	1% Siaα2,6-CRBC	HA 226 residue^c	Transmission^d
A/Chicken/Shandong/Li-2/2010(SD2/H9N2)	>6.5	64	32	F	0/3
A/Chicken/Shandong/Li-2/2010 (SD3/H9N2)	>6.5	64	32	L	0/3
A/Chicken/Jilin/Hu-3/2006(JL3/H9N2)	>6.5	64	<2	Q	0/3

^aPathogenicity for mice was evaluated as MLD₅₀ value (expressed as log₁₀EID₅₀).

^bHemagglutination test of viruses for chicken red blood cells (CRBCs) possessing both α2,3-linked sialic acids (SAs) and α2,6-linked SAs, or CRBCs treated with α2,3-Sialidase, leaving predominantly α2,6-linked SAs.

^cThe amino acid residues at HA amino acid position 226 (H3 HA numbering).

^dDirect contact transmission in guinea pig model.