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. 2015 Nov 9;211(3):569–586. doi: 10.1083/jcb.201506048

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© 2015 Schreiber et al.

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Figure 2. — Short-term contextual fear memory is enhanced in Trim3^−/− mice. (A) Animals received a foot shock (unconditioned stimulus; US) in a novel context (conditioned stimulus; CS). Memory retrieval was tested either 2 h (short-term memory; STM) or 24 h (long-term memory; LTM) after conditioning in two independent cohorts of mice. (B) Freezing behavior was significantly increased in 3-mo-old Trim3^−/− mice compared with wild-type littermates when reexposed to the conditioned context 2h after receiving the shock (STM), but not at 24 h (LTM), indicating enhanced consolidation of fear memory (means ± SEM, two-tailed t test, *, P < 0.05, n = 8/10 per genotype). (C) A similar increase in freezing behavior at 2 h, but not at 24 h, after the shock was observed in 8-mo-old Trim3^−/− mice (means ± SEM, two-tailed t test, *, P < 0.05, n = 5/7 per genotype).