Table 1. Behavioral analysis of Trim3−/− mice at 3 mo of age.
| Test/test measure | Unit | Wild type (n = 12) | Knockout (n = 12) | P-value |
|---|---|---|---|---|
| Open field/Ethovision | ||||
| Number of entries into the center area | 84.83 ± 4.07 | 91.67 ± 6.36 | 0.375 | |
| Time spent in the center area | s | 314.5 ± 18.0 | 308.0 ± 18.4 | 0.803 |
| Total distance traveled | cm | 5,602 ± 264 | 5,819 ± 345 | 0.622 |
| Open field/SEE analysis/velocity | ||||
| Lingering progression threshold speed | cm/s | 12.05 ± 0.61 | 12.89 ± 0.83 | 0.418 |
| Median of move segment maximum speed | cm/s | 24.03 ± 0.69 | 25.01 ± 1.00 | 0.425 |
| Quantile 95 of move segment maximum speed | cm/s | 35.80 ± 0.89 | 35.54 ± 1.03 | 0.850 |
| Lingering mean speed | cm/s | 1.65 ± 0.10 | 1.66 ± 0.10 | 0.988 |
| Median of lingering segment maximum speed | cm/s | 3.17 ± 0.40 | 2.28 ± 0.60 | 0.231 |
| Open field/SEE analysis/acceleration | ||||
| Latency to maximum half speed | s | 8.65 ± 3.84 | 5.88 ± 1.62 | 0.513 |
| Median segment acceleration to maximum speed | cm/s2 | 15.77 ± 0.69 | 15.44 ± 0.57 | 0.715 |
| Open field/SEE analysis/other | ||||
| Number of progression segments | segments | 143.3 ± 10.7 | 142.0 ± 10.2 | 0.934 |
| Median length of progression segments | cm | 24.73 ± 0.96 | 28.40 ± 2.08 | 0.123 |
| Median duration of progression segments | s | 1.55 ± 0.05 | 1.63 ± 0.07 | 0.369 |
| Quantile 5 of duration of progression segments | s | 0.55 ± 0.03 | 0.57 ± 0.04 | 0.755 |
| Quantile 95 of duration of progression segments | s | 3.38 ± 0.10 | 3.62 ± 0.14 | 0.172 |
| Number of stops per distance | segments/cm | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.386 |
| Time proportion of lingering episodes | 0.59 ± 0.03 | 0.58 ± 0.03 | 0.651 | |
| Median radius of turn | cm | 77.69 ± 3.74 | 81.05 ± 3.41 | 0.513 |
| Median turn rate | degrees/s | 14.06 ± 0.58 | 13.83 ± 0.48 | 0.761 |
| Light-dark box | ||||
| Number of entries into the light compartment | 29.50 ± 3.30 | 38.00 ± 3.67 | 0.099 | |
| Time spent in the light compartment | s | 301.1 ± 17.2 | 305.2 ± 16.7 | 0.863 |
| Elevated plus maze | ||||
| Number of entries into the closed arms | 22.00 ± 1.93 | 23.50 ± 1.81 | 0.576 | |
| Number of entries into the open arms | 28.42 ± 2.94 | 32.75 ± 2.66 | 0.287 | |
| Number of entries into the middle | 25.92 ± 2.53 | 29.58 ± 2.18 | 0.284 | |
| Time spent in the closed arms | s | 419.8 ± 15.0 | 395.7 ± 7.9 | 0.171 |
| Time spent in the open arms | s | 159.7 ± 12.6 | 175.2 ± 8.3 | 0.315 |
| Time spent in the middle | s | 84.64 ± 7.37 | 110.07 ± 7.87 | 0.028 |
| Total distance moved | cm | 1,552 ± 86 | 1,608 ± 76 | 0.632 |
Entries show mean ± SEM values unless otherwise indicated.