Table 1. .
Strength of Recommendation |
Definition |
A | Recommendation based on consistent and good quality experimental evidence (morbidity, mortality, exercise and cognitive performance, physiologic responses). |
B | Recommendation based on inconsistent or limited quality experimental evidence. |
C | Recommendation based on consensus; usual practice; opinion; disease-oriented evidenceb; case series or studies of diagnosis, treatment, prevention, or screening; or extrapolations from quasi-experimental research. |
Reprinted with permission from Ebell MH, Siwek J, Weiss BD, et al, Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature, 2004;69(3):548–556, Am Fam Physician. Copyright 2004 American Academy of Family Physicians. All Rights Reserved.14
Patient-oriented evidence measures outcomes that matter to patients: morbidity, mortality, symptoms improvement, cost reduction, and quality of life. Disease-oriented evidence measures intermediate, physiologic, or surrogate end points that may or may not reflect improvements in patient outcomes (eg, blood pressure, blood chemistry, physiologic function, pathologic finding).