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. 2015 Sep 28;125(11):4063–4076. doi: 10.1172/JCI82152

Figure 8. Low LKB1 protein levels in primary human endometrial cancers are strongly correlated with high CCL2 expression and increased macrophage density.

Figure 8

A human endometrial cancer TMA was stained and scored for each marker per the schematic in Supplemental Figure 6. A total of 175 separate cases of primary endometrial cancer were scored. Pair-wise correlations were evaluated by Kendall’s τ coefficient, with P values determined by 2-tailed t tests. (A) Heat maps showing significant negative correlations among grade 1 and grade 1–3 endometrial adenocarcinomas. (B) Top panels: number of cases with specific staining scores (grades 0–3) among tumors of different clinical stages (FIGO 1A, 1B, 1C). Of cases with more than 50% myometrial invasion (defined as stage 1C), the percentage with low LKB1 expression or high CCL2/CD68 expression was significantly increased. Bottom panels: number of cases with specific staining scores (grades 0–3) among tumors of different histopathological grades (grades 1, 2, 3). There was a significantly greater percentage of cases expressing low levels of LKB1 protein among high-grade tumors (n = 113). Additionally, there was a significantly greater percentage of cases expressing high levels of CCL2 (n = 113) and CD68 (n = 113) among high-grade tumors. *P < 0.005; **P < 0.001, Fisher’s exact t test.