Table 5.
The top 30 differentially enriched gene ontology pathways among hits for sex in autosomal CpGs
| Genes | |||||
|---|---|---|---|---|---|
| GO category | Category name | Total | Changed | P-value | FDR |
| GO:0043005 | Neuron projection | 651 | 67 | 2.22E-05 | 0.00E + 00 |
| GO:0007275 | Multicellular organismal development | 4621 | 353 | 9.06E-12 | 4.91E-09 |
| GO:0097458 | Neuron part | 980 | 104 | 8.83E-11 | 8.47E-09 |
| GO:0044767 | Single-organism developmental process | 5402 | 394 | 2.05E-10 | 1.24E-08 |
| GO:0048856 | Anatomical structure development | 4828 | 359 | 2.43E-10 | 1.24E-08 |
| GO:0007268 | Synaptic transmission | 692 | 78 | 1.50E-09 | 5.09E-08 |
| GO:0048731 | System development | 4093 | 311 | 5.69E-10 | 1.54E-07 |
| GO:0007270 | Neuron-neuron synaptic transmission | 129 | 26 | 3.30E-09 | 4.76E-07 |
| GO:0007267 | Cell-cell signaling | 1192 | 115 | 3.51E-09 | 4.76E-07 |
| GO:0043167 | Ion binding | 6038 | 422 | 2.02E-08 | 1.25E-06 |
| GO:0007626 | Locomotory behavior | 186 | 30 | 1.25E-07 | 3.19E-06 |
| GO:0032879 | Regulation of localization | 2010 | 168 | 4.15E-08 | 4.50E-06 |
| GO:0044707 | Single-multicellular organism process | 6462 | 438 | 2.47E-07 | 5.04E-06 |
| GO:0009653 | Anatomical structure morphogenesis | 2484 | 196 | 2.97E-07 | 5.05E-06 |
| GO:0044765 | Single-organism transport | 3605 | 262 | 1.79E-06 | 2.36E-05 |
| GO:0044763 | Single-organism cellular process | 11,949 | 739 | 1.85E-06 | 2.36E-05 |
| GO:0009790 | Embryo development | 998 | 94 | 5.15E-07 | 4.66E-05 |
| GO:1902578 | Single-organism localization | 3791 | 271 | 4.22E-06 | 4.79E-05 |
| GO:0007399 | Nervous system development | 2053 | 171 | 4.97E-08 | 4.81E-05 |
| GO:0065008 | Regulation of biological quality | 3239 | 236 | 4.77E-06 | 4.86E-05 |
| GO:0051703 | Intraspecies interaction between organisms | 40 | 11 | 6.02E-06 | 5.58E-05 |
| GO:0009887 | Organ morphogenesis | 918 | 87 | 9.65E-07 | 6.55E-05 |
| GO:0048513 | Organ development | 2958 | 222 | 9.66E-07 | 6.55E-05 |
| GO:0036477 | Somatodendritic compartment | 562 | 60 | 1.10E-06 | 8.50E-05 |
| GO:0044459 | Plasma membrane part | 2279 | 174 | 1.90E-06 | 9.14E-05 |
| GO:0016043 | Cellular component organization | 5410 | 366 | 1.68E-05 | 1.43E-04 |
| GO:0030425 | Dendrite | 378 | 45 | 1.15E-06 | 1.70E-04 |
| GO:0051705 | Multi-organism behavior | 79 | 15 | 2.27E-05 | 1.78E-04 |
| GO:0005883 | Neurofilament | 9 | 6 | 2.54E-06 | 1.88E-04 |
| GO:0035637 | Multicellular organismal signaling | 751 | 86 | 7.94E-08 | 2.00E-04 |