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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Circ Res. 2014 Jun 11;115(5):525–532. doi: 10.1161/CIRCRESAHA.115.303881

Figure 3. Role of mitochondria in FID in ceramide exposed vessels.

Figure 3

A, Vasodilation in response to flow is impaired in arterioles pre-treated with ceramide and rotenone compared to ceramide alone. Rotenone alone had no effect on FID (n=5, 10, and 5, respectively). B, Mito-TEMPO significantly decreased the response to flow in ceramide-treated vessels compared to ceramide alone. Mito-TEMPO alone had no effect (n=5, 10, and 5, respectively). † p<0.05 vs. ceramide curve. *p<0.05 vs. ceramide at specific pressure gradients.