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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Circ Res. 2014 Jun 11;115(5):525–532. doi: 10.1161/CIRCRESAHA.115.303881

Figure 5. Inhibition of NSmase reverts the mediator of FID back to NO in vessels from adipose tissue from patients with CAD.

Figure 5

A, Incubation with the specific NSmase inhibitor GW4869 (4μM, 16-20hrs) did not affect the overall magnitude of dilation to flow compared to vehicle-treated control (n=9 and 8, respectively). B, The response to flow was inhibited in CAD vessels first incubated with GW4869 in the presence of L-NAME (100μM) compared to GW4869 alone, whereas PEG-catalase (500U) had no effect (n=5, 9, and 5, respectively). *p<0.05 vs. GW4869 at specific pressure gradients.