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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Adv Healthc Mater. 2015 May 4;4(10):1484–1423. doi: 10.1002/adhm.201400841

Figure 3.

Figure 3

SNO-NP-mediated killing of adult female B. malayi filarial worms is accelerated with increasing ratios of low molecular weight thiol cysteine (CYS) to SNO-NP. Worm motility (a) is reduced by NO donors SNO-NP and S-N-acetyl penicillamine (SNAP) and results in worm death at similar times (b). (c) Increasing ratio of CYS to SNO-NP accelerates SNO-NP-mediated reductions in worm motility. (d-e) Worm death induced by SNO-NP occurs more quickly at the highest ratios of CYS to SNO-NP relative to SNAP. Data in all panels from at least two independently run experiments. (a, c) Data represent the average motility of of n≥8 worms. (b, d), *** and §§§ p<0.001 by Log-rank test. (e), *p<0.5 by one-way ANOVA with multiparameter comparison correction (Tukey's test). (f) Shortest time until worm death induced by SNO-NP corresponds to the ratio of CYS to SNO-NP that results in the highest observed levels of formed SNO-CYS concentrations. In all experiments, SNO-NP and SNAP concentrations of 1-2 mM SNO were used.