Table 3.
Linear regression results for immunoglobulin levels.
| Variable | Gene | Position | SNP | Genotype | N | Median antibody level (µg/ml) |
Mean antibody level (µg/ml) |
CI (95%) | P |
|---|---|---|---|---|---|---|---|---|---|
| IgG | HLA-F | −6607 | rs2517911 | AA | 82 | 711.75 | 779.3 | 704.2, 854.41 | |
| AG | 48 | 565.7 | 593.31 | 528.77, 657.85 | |||||
| GG | 4 | 467.05 | 422.65 | 239.3, 606 | 3.55E–05 | ||||
| IgG | HLA-F | −1219 | rs1628578 | AA | 79 | 712.1 | 781.93 | 704.55, 859.3 | |
| AC | 51 | 565.8 | 600.19 | 537.27, 663.1 | |||||
| CC | 4 | 467.05 | 422.65 | 239.3, 606 | 5.59E–05 | ||||
| IgG | FLJ35429 | −3984 | rs1611350 | AA | 73 | 711.4 | 781.82 | 701.95, 861.69 | |
| AG | 52 | 600.15 | 637.3 | 566.7, 707.91 | |||||
| GG | 9 | 482.6 | 428.9 | 333.78, 524.02 | 2.18E–05 | ||||
| IgG | FLJ35429 | −2622 | rs1610601 | AA | 4 | 467.05 | 422.65 | 239.3, 606 | |
| AC | 46 | 574.35 | 602.82 | 537.73, 667.92 | |||||
| CC | 84 | 705.6 | 769.67 | 694.93, 844.4 | 0.0002386 | ||||
| IgG | FLJ35429 | −76 | rs1633088 | AA | 76 | 713 | 792.14 | 711.74, 872.53 | |
| AG | 44 | 583.25 | 607.69 | 542.78, 672.59 | |||||
| GG | 5 | 440.9 | 408.06 | 277.7, 538.42 | 5.69E–05 | ||||
| IgG1 | HLA-F | −6607 | rs2517911* | AA | 82 | 698.85 | 771.48 | 692.1, 850.86 | |
| AG | 48 | 595.9 | 639.54 | 550.28, 728.8 | |||||
| GG | 4 | 331.2 | 317 | 240.95, 393.05 | 0.000619 | ||||
| IgG1 | HLA-F | −1219 | rs1628578* | AA | 79 | 700.1 | 779.57 | 698.26, 860.87 | |
| AC | 51 | 594 | 634.78 | 549.34, 720.22 | |||||
| CC | 4 | 331.2 | 317 | 240.95, 393.05 | 0.0003055 | ||||
| IgG1 | FLJ35429 | −3984 | rs1611350* | AA | 73 | 700.1 | 780.94 | 697.15, 864.72 | |
| AG | 52 | 626.2 | 663.82 | 573.44, 754.2 | |||||
| GG | 9 | 357.4 | 411.21 | 276.69, 545.74 | 0.0001011 | ||||
| IgG1 | FLJ35429 | −76 | rs1633088* | AA | 76 | 735.55 | 792.73 | 709.36, 876.1 | |
| AG | 44 | 595.9 | 637.62 | 545.94, 729.31 | |||||
| GG | 5 | 324.7 | 310.28 | 255.6,364.96 | 8.80E–05 | ||||
| IgG4 | C6orf10 | −395 | rs2050190 | AA | 72 | 1.3 | 9.28 | 3.6,14.95 | |
| AG | 53 | 2.5 | 15.55 | 3.27, 27.82 | |||||
| GG | 9 | 44.4 | 188.8 | −86.14, 463.74 | 0.0007056 | ||||
| IgG4 | BTNL2 | −14748 | rs3135363 | AA | 66 | 0.85 | 7.45 | 2.12,12.78 | |
| AG | 54 | 3.35 | 45.19 | 1.7, 88.67 | |||||
| GG | 5 | 8.5 | 30.36 | −15.21, 75.93 | 0.0008295 | ||||
| IgM | RFP | −8611 | rs381808 | AA | 42 | 120.8 | 779.3 | 112.77,157.81 | |
| AT | 56 | 144.25 | 593.31 | 133.46,166.53 | |||||
| TT | 27 | 193.2 | 422.65 | 158.51, 204.52 | 0.0005431 | ||||
| IgM | RFP | −4252 | rs3130838 | AA | 106 | 149.6 | 781.93 | 147.11,172.65 | |
| AG | 19 | 96.5 | 600.19 | 84.14,130.14 | |||||
| GG | 0 | – | 422.65 | – | 0.0005307 | ||||
| IgM | RFP | −2162 | rs2894066 | AA | 29 | 101 | 781.82 | 93.9,130.27 | |
| AG | 58 | 147 | 637.3 | 136.9,174.9 | |||||
| GG | 47 | 164.1 | 428.9 | 150.05, 185.03 | 5.55E–05 | ||||
| IgM | RFP | −2579 | rs1237485† | AA | 44 | 117.35 | 422.65 | 110.86, 154.48 | |
| AG | 53 | 145.2 | 602.82 | 135.54,169.56 | |||||
| GG | 28 | 187.3 | 769.67 | 158.53, 202.91 | 0.0001627 | ||||
| IgM | RFP | −6522 | rs3118361 | AA | 0 | – | 792.14 | – | |
| AG | 19 | 96.5 | 607.69 | 84.14,130.14 | |||||
| GG | 106 | 149.6 | 408.06 | 147.11,172.65 | 0.0005307 | ||||
| IgM | RFP | −13339 | rs3135329*,† | AA | 27 | 98 | 779.3 | 92.26,131.5 | |
| AT | 52 | 147 | 593.31 | 136.67,177.48 | |||||
| TT | 46 | 161.95 | 422.65 | 152.26,186.62 | 4.12E–05 | ||||
| IgM | RFP | −16449 | rs3130843 | AA | 29 | 108.1 | 781.93 | 95.38,149.25 | |
| AT | 54 | 147 | 600.19 | 133.78,169.07 | |||||
| TT | 42 | 171.5 | 422.65 | 154.52,191.14 | 6.55E–05 | ||||
| IgM | RFP | −23343 | rs763009† | AA | 27 | 193.2 | 781.82 | 161.51, 205.6 | |
| AG | 54 | 145.1 | 637.3 | 134.81,168.5 | |||||
| GG | 44 | 117.35 | 428.9 | 110.86, 154.48 | 9.52E–05 | ||||
| IgM | RFP | −55155 | rs3135322† | AA | 28 | 187.3 | 422.65 | 157.93, 202.51 | |
| AG | 51 | 146.9 | 602.82 | 135.21,170.58 | |||||
| GG | 46 | 120.8 | 769.67 | 112.59,154.33 | 0.0001742 | ||||
| IgM | OR2W1 | −4129 | rs3130756† | AA | 42 | 117.35 | 792.14 | 108.58, 153.24 | |
| AG | 54 | 147.75 | 607.69 | 137.05, 171.04 | |||||
| GG | 29 | 181.4 | 408.06 | 156.26, 200.03 | 8.70E–05 | ||||
| IgM | OR2W1 | −18170 | rs3117143 | AA | 0 | – | 779.3 | – | |
| AC | 19 | 96.5 | 593.31 | 84.14,130.14 | |||||
| CC | 106 | 149.6 | 422.65 | 147.11,172.65 | 0.0005307 | ||||
| IgM | OR2J3 | −6574 | rs3131091† | AA | 42 | 117.35 | 781.93 | 108.58, 153.24 | |
| AG | 54 | 147.75 | 600.19 | 137.05, 171.04 | |||||
| GG | 29 | 181.4 | 422.65 | 156.26, 200.03 | 8.70E–05 | ||||
| IgM | OR2J3 | −6226 | rs3130766l† | AA | 42 | 117.35 | 781.82 | 108.58, 153.24 | |
| AG | 54 | 147.75 | 637.3 | 137.05, 171.04 | |||||
| GG | 29 | 181.4 | 428.9 | 156.26, 200.03 | 8.70E–05 | ||||
| IgM | OR2J2 | −19782 | rs3129126l† | AA | 29 | 181.4 | 422.65 | 156.26, 200.03 | |
| AG | 53 | 146.9 | 602.82 | 136.83,171.47 | |||||
| GG | 43 | 117.7 | 769.67 | 109.52, 153.12 | 0.0001131 | ||||
| IgM | OR2J2 | −17278 | rs3129173 | AA | 106 | 149.6 | 792.14 | 147.11, 172.65 | |
| AC | 19 | 96.5 | 607.69 | 84.14, 130.14 | |||||
| CC | 0 | – | 408.06 | – | 0.0005307 | ||||
| IgM | OR2J2 | −21483 | rs1977074 | AA | 29 | 164.1 | 779.3 | 149.27, 194.49 | |
| AG | 53 | 150.6 | 593.31 | 140.22, 174.93 | |||||
| GG | 43 | 117.7 | 422.65 | 109.52, 153.12 | 0.0004792 | ||||
| IgM | OR2J2 | −25224 | rs3116830 | AA | 0 | – | 781.93 | – | |
| AG | 19 | 96.5 | 600.19 | 84.14, 130.14 | |||||
| GG | 106 | 149.6 | 422.65 | 147.11, 172.65 | 0.0005307 | ||||
| IgM | OR5U1 | −51756 | rs12182511† | CC | 41 | 117.7 | 781.82 | 109.54, 155.15 | |
| CG | 56 | 145.1 | 637.3 | 137.37, 171.18 | |||||
| GG | 28 | 172.75 | 428.9 | 153.55, 197.7 | 0.000253 | ||||
| IgM | OR5U1 | −34089 | rs3117326 | AA | 0 | – | 422.65 | – | |
| AG | 19 | 96.5 | 602.82 | 84.14, 130.14 | |||||
| GG | 106 | 149.6 | 769.67 | 147.11, 172.65 | 0.0005307 | ||||
| IgM | OR5U1 | −23067 | rs6456942 | AA | 29 | 164.1 | 792.14 | 149.27, 194.49 | |
| AG | 54 | 148.75 | 607.69 | 139.07, 173.5 | |||||
| GG | 42 | 120.8 | 408.06 | 110.12, 154.6 | 0.000678 | ||||
| IgM | OR10C1 | −2701 | rs1535039 | AA | 106 | 149.6 | 779.3 | 147.11, 172.65 | |
| AG | 19 | 96.5 | 593.31 | 84.14, 130.14 | |||||
| GG | 0 | – | 422.65 | – | 0.0005307 | ||||
| IgM | OR2H1 | −3258 | rs2746149† | AA | 104 | 149.6 | 781.93 | 147.33, 173.09 | |
| AG | 21 | 96.5 | 600.19 | 87.28, 133.78 | |||||
| GG | 0 | – | 422.65 | – | 0.0004298 | ||||
| IgM | OR2H1 | −10604 | rs2746150 | AA | 0 | – | 781.82 | – | |
| AG | 19 | 96.5 | 637.3 | 84.14, 130.14 | |||||
| GG | 106 | 149.6 | 428.9 | 147.11, 172.65 | 0.0005307 | ||||
| IgM | MAS1L | −7364 | rs1233489 | AA | 0 | – | 422.65 | – | |
| AT | 19 | 96.5 | 602.82 | 84.14, 130.14 | |||||
| TT | 106 | 149.6 | 769.67 | 147.11, 172.65 | 0.0005307 | ||||
| IgM | MAS1L | −22142 | rs1233478† | AA | 6 | 112.3 | 792.14 | 48.49, 184.34 | |
| AC | 44 | 115.05 | 607.69 | 112.46, 149.42 | |||||
| CC | 75 | 156.1 | 408.06 | 151.76, 182.19 | 9.24E–05 | ||||
| IgM | FLJ35429 | −3984 | rs1611350 | AA | 73 | 159.3 | 779.3 | 148.59, 180.55 | |
| AG | 52 | 134.3 | 593.31 | 124.18, 157.44 | |||||
| GG | 9 | 77.5 | 422.65 | 60.74, 124.12 | 0.0003157 | ||||
| IgM | FLJ35429 | −2622 | rs1610601 | AA | 4 | 110.45 | 781.93 | 49.58, 155.02 | |
| AC | 46 | 122.25 | 600.19 | 112.39, 150.36 | |||||
| CC | 84 | 158.45 | 422.65 | 149.06, 177.48 | 0.0008349 | ||||
| IgM | HLA-G | −19782 | rs2734985 | AA | 83 | 159.8 | 781.82 | 151.82, 182.1 | |
| AG | 40 | 125.3 | 637.3 | 108.8, 139.77 | |||||
| GG | 2 | 76.8 | 428.9 | –192.57,346.17 | 0.0001734 | ||||
| IgM | HCG9 | −33622 | rs356971 | AA | 92 | 159.55 | 422.65 | 150.68,178.76 | |
| AC | 33 | 117.7 | 602.82 | 99.27, 132.76 | |||||
| CC | 0 | – | 769.67 | – | 0.0001766 | ||||
| IgM | RNF39 | [86/195] | rs9261290 | AA | 105 | 150.6 | 792.14 | 147.63, 173.3 | |
| AG | 20 | 97.25 | 607.69 | 84.92, 128.45 | |||||
| GG | 0 | – | 408.06 | – | 0.0003493 | ||||
| IgM | TRIM39 | −15910 | rs3130380 | AA | 0 | – | 779.3 | – | |
| AG | 18 | 97.25 | 593.31 | 82.48, 130.33 | |||||
| GG | 107 | 148.6 | 422.65 | 146.82, 172.2 | 0.00063 | ||||
| IgM | HLA-C | −4934 | rs2524069 | AA | 105 | 150.6 | 781.93 | 147.36, 173.05 | |
| AT | 27 | 117 | 600.19 | 98.84, 140.4 | |||||
| TT | 2 | 58.1 | 422.65 | 12.36, 103.84 | 0.0001513 | ||||
| IgM | HLA-DRA | −8386 | rs3135339 | CC | 15 | 107 | 781.82 | 85.73, 134.13 | |
| CG | 44 | 128.15 | 637.3 | 118.03, 150.29 | |||||
| GG | 75 | 164.1 | 428.9 | 151.82, 184.59 | 0.0004524 | ||||
| IgM | HLA-DRA | −7805 | rs2395172 | AA | 75 | 164.1 | 422.65 | 151.82, 184.59 | |
| AG | 44 | 128.15 | 602.82 | 118.03, 150.29 | |||||
| GG | 15 | 107 | 769.67 | 85.73, 134.13 | 0.0004524 | ||||
| IgM | HLA-DRA | −6708 | rs3129859 | CC | 71 | 164.1 | 792.14 | 149.78, 182.94 | |
| CG | 45 | 129.6 | 607.69 | 124.19, 159.98 | |||||
| GG | 18 | 104 | 408.06 | 87.67, 130.35 | 0.0007321 | ||||
| IgM | HLA-DRA | −3992 | rs983561 | AA | 75 | 164.1 | 779.3 | 151.82, 184.59 | |
| AC | 44 | 128.15 | 593.31 | 118.03, 150.29 | |||||
| CC | 15 | 107 | 422.65 | 85.73, 134.13 | 0.0004524 | ||||
| IgM | HLA-DRA | −2571 | rs2395177 | CC | 14 | 108.85 | 781.93 | 87.77, 138.19 | |
| CG | 40 | 126.75 | 600.19 | 114.85, 147.64 | |||||
| GG | 71 | 165.7 | 422.65 | 154.28, 188.01 | 0.0003933 | ||||
| IgM | HLA-DRA | −494 | rs3129872 | AA | 15 | 107 | 781.82 | 85.73, 134.13 | |
| AT | 44 | 128.15 | 637.3 | 118.03, 150.29 | |||||
| TT | 75 | 164.1 | 428.9 | 151.82, 184.59 | 0.0004524 |
*
Markers that had significant p-values in logistic regression with binary cut-off 10%.
†
Markers that had significant p-values in logistic regression with binary cut-off 15.
Underlined markers were significant in PCA.
Bold markers are significant in haplotype analysis.