Table 3.
Changes in conditional probability associated with perturbation of PRL and structural hubs
| Cytokine | Low | Medium | High |
|---|---|---|---|
| PRL | 0.065 | 0.692 | 0.243 |
| P4 | 0.066 | 0.786 | 0.148 |
| P4-PRL | 0.778 | 0.111 | 0.111 |
| P4-PRL+IL-13 | 0.778 | 0.111 | 0.111 |
| P4-PRL+MCP-1 | 0.778 | 0.111 | 0.111 |
| P4-PRL+IL-13+MCP-1 | 0.778 | 0.111 | 0.111 |
| IL-13 | 0.400 | 0.499 | 0.101 |
| IL-13-PRL | 0.379 | 0.348 | 0.272 |
| IL-13-PRL+IL-13 | 0.000 | 0.000 | 1.000 |
| IL-13-PRL+MCP-1 | 0.379 | 0.348 | 0.272 |
| IL-13-PRL+IL-13+MCP-1 | 0.000 | 0.000 | 1.000 |
| IL-2 | 0.274 | 0.602 | 0.124 |
| IL-2-PRL | 0.274 | 0.481 | 0.246 |
| IL-2-PRL+IL-13 | 0.111 | 0.111 | 0.778 |
| IL-2-PRL+MCP-1 | 0.274 | 0.481 | 0.246 |
| IL-2-PRL+IL-13+MCP-1 | 0.111 | 0.111 | 0.778 |
| MCP-1 | 0.431 | 0.458 | 0.111 |
| MCP-1-PRL | 0.418 | 0.386 | 0.196 |
| MCP-1-PRL+IL-13 | 0.200 | 0.229 | 0.571 |
| MCP-1-PRL+MCP-1 | 0.000 | 0.000 | 1.000 |
| MCP-1-PRL+IL-13+MCP-1 | 0.000 | 0.000 | 1.000 |
| GM-CSF | 0.359 | 0.526 | 0.115 |
| GM-CSF-PRL | 0.353 | 0.469 | 0.178 |
| GM-CSF-PRL+IL-13 | 0.225 | 0.316 | 0.458 |
| GM-CSF-PRL+MCP-1 | 0.111 | 0.111 | 0.778 |
| GM-CSF-PRL+IL-13+MCP-1 | 0.111 | 0.111 | 0.778 |
| MIP-1α | 0.235 | 0.687 | 0.078 |
| MIP-1α-PRL | 0.250 | 0.644 | 0.106 |
| MIP-1α-PRL+IL-13 | 0.250 | 0.521 | 0.229 |
| MIP-1α-PRL+MCP-1 | 0.270 | 0.360 | 0.370 |
| MIP-1α-PRL+IL-13+MCP-1 | 0.270 | 0.360 | 0.370 |
| MIP-1β | 0.607 | 0.208 | 0.186 |
| MIP-1β-PRL | 0.570 | 0.224 | 0.205 |
| MIP-1β-PRL+IL-13 | 0.434 | 0.293 | 0.273 |
| MIP-1β-PRL+MCP-1 | 0.321 | 0.357 | 0.321 |
| MIP-1β-PRL+IL-13+MCP-1 | 0.321 | 0.357 | 0.321 |
| KC | 0.165 | 0.706 | 0.129 |
| KC-PRL | 0.168 | 0.692 | 0.140 |
| KC-PRL+IL-13 | 0.183 | 0.635 | 0.181 |
| KC-PRL+MCP-1 | 0.201 | 0.569 | 0.230 |
| KC-PRL+IL-13+MCP-1 | 0.201 | 0.569 | 0.230 |
| IL-1α | 0.626 | 0.223 | 0.151 |
| IL-1α-PRL | 0.605 | 0.230 | 0.165 |
| IL-1α-PRL+IL-13 | 0.528 | 0.256 | 0.216 |
| IL-1α-PRL+MCP-1 | 0.465 | 0.281 | 0.254 |
| IL-1α-PRL+IL-13+MCP-1 | 0.465 | 0.281 | 0.254 |
| IL-10 | 0.648 | 0.230 | 0.122 |
| IL-10-PRL | 0.622 | 0.245 | 0.133 |
| IL-10-PRL+IL-13 | 0.526 | 0.301 | 0.173 |
| IL-10-PRL+MCP-1 | 0.448 | 0.348 | 0.204 |
| IL-10-PRL+IL-13+MCP-1 | 0.448 | 0.348 | 0.204 |
| IFN-γ | 0.504 | 0.299 | 0.197 |
| IFN-γ-PRL | 0.465 | 0.299 | 0.236 |
| IFN-γ-PRL+IL-13 | 0.325 | 0.337 | 0.338 |
| IFN-γ-PRL+MCP-1 | 0.352 | 0.325 | 0.323 |
| IFN-γ-PRL+IL-13+MCP-1 | 0.316 | 0.341 | 0.343 |
| IL-5 | 0.517 | 0.327 | 0.156 |
| IL-5-PRL | 0.487 | 0.336 | 0.177 |
| IL-5-PRL+IL-13 | 0.377 | 0.386 | 0.237 |
| IL-5-PRL+MCP-1 | 0.398 | 0.375 | 0.228 |
| IL-5-PRL+IL-13+MCP-1 | 0.370 | 0.390 | 0.240 |
| IL-17 | 0.513 | 0.391 | 0.096 |
| IL-17-PRL | 0.486 | 0.406 | 0.108 |
| IL-17-PRL+IL-13 | 0.390 | 0.467 | 0.144 |
| IL-17-PRL+MCP-1 | 0.407 | 0.454 | 0.138 |
| IL-17-PRL+IL-13+MCP-1 | 0.384 | 0.470 | 0.146 |
| IL-6 | 0.608 | 0.306 | 0.086 |
| IL-6-PRL | 0.585 | 0.319 | 0.096 |
| IL-6-PRL+IL-13 | 0.506 | 0.371 | 0.123 |
| IL-6-PRL+MCP-1 | 0.521 | 0.361 | 0.119 |
| IL-6-PRL+IL-13+MCP-1 | 0.501 | 0.374 | 0.124 |
| RANTES | 0.483 | 0.276 | 0.241 |
| RANTES-PRL | 0.454 | 0.287 | 0.259 |
| RANTES-PRL+IL-13 | 0.373 | 0.322 | 0.305 |
| RANTES-PRL+MCP-1 | 0.328 | 0.347 | 0.326 |
| RANTES-PRL+IL-13+MCP-1 | 0.327 | 0.347 | 0.326 |
| TNF-α | 0.372 | 0.317 | 0.311 |
| TNF-α-PRL | 0.364 | 0.321 | 0.316 |
| TNF-α-PRL+IL-13 | 0.346 | 0.328 | 0.325 |
| TNF-α-PRL+MCP-1 | 0.341 | 0.331 | 0.329 |
| TNF-α-PRL+IL-13+MCP-1 | 0.340 | 0.331 | 0.329 |
Conditional probabilities are given to each of three bins (low, medium and high). Highest conditional probability values in any given bin indicate a greater likelihood of the relevant mediator’s concentration being in that concentration bin. The large font denotes the node of interest; small font indicates the perturbed parent node; a ‘-’ sign indicates perturbation by reducing concentration while a ‘+’ sign indicates perturbation by increasing concentration