Table 1.

Main characteristics of studies included in the meta-analysis

Study	Year	Ethnicity	Tumor cases	Normal controls	Methods	Materials
Antelo et al (early onset)20	2012	Non-Asian	185	32	Pyrosequencing	FFPE
Antelo et al (Lynch syndrome)20	2012	Non-Asian	20	32	Pyrosequencing	FFPE
Antelo et al (older onset sporadic MSI)20	2012	Non-Asian	46	32	Pyrosequencing	FFPE
Antelo et al (older onset sporadic MSS)20	2012	Non-Asian	89	32	Pyrosequencing	FFPE
Matsunoki et al21	2012	Asian	48	48	Multicolor MethyLight assay	FFPE
Hur et al22	2014	Non-Asian	77	77	Pyrosequencing	FFPE
Rhee et al23	2012	Asian	207	NA	Pyrosequencing	FFPE
Estecio et al12	2007	Non-Asian	60	60	Pyrosequencing	Fresh tissues
Pavicic et al (sporadic MSS)24	2012	Non-Asian	55	55	COBRA	FFPE
Pavicic et al (sporadic MSI)24	2012	Non-Asian	52	52	COBRA	FFPE
Pavicic et al (Lynch syndrome)24	2012	Non-Asian	43	43	COBRA	FFPE
Pavicic et al (FCCX)24	2012	Non-Asian	18	18	COBRA	FFPE
Imamura et al25	2014	Non-Asian	1,267	NA	Pyrosequencing	FFPE
Morikawa et al26	2012	Non-Asian	1,060	NA	Pyrosequencing	FFPE
Shima et al27	2011	Non-Asian	1,072	NA	Pyrosequencing	FFPE
Baba et al10	2010	Non-Asian	869	NA	Pyrosequencing	FFPE
Hazra et al28	2010	Non-Asian	182	NA	Pyrosequencing	FFPE
Ogino et al29	2009	Non-Asian	647	NA	Pyrosequencing	FFPE
Ogino et al30	2009	Non-Asian	82	NA	Pyrosequencing	FFPE
Lou et al31	2015	Asian	129	NA	Pyrosequencing	FFPE
Yamauchi et al32	2012	Non-Asian	1188	NA	Pyrosequencing	FFPE

Abbreviations: COBRA, combined bisulfite restriction analysis; FCCX, familial colorectal cancer type X; FFPE, formalin fixed paraffin embedded; MSI, microsatellite instability; MSS, microsatellite stability; NA, not available.