Table S3.

PIP decisions removed from analysis as listed in duplication (3 decisions)

Pazopanib	RMS, non-RMS STS, Ewing sarcoma	EMEA-000601-PIP01-09-M02	SEP2021
Recomb l-AGN	ALL and lymphoblastic lymphoma	EMEA-000013-PIP01-07-M03	NOV2012
CSF/fusion protein	Prevention of CT induced neutropenia	EMEA-001042-PIP01-10	Refused W

Abbreviations: STS, soft tissue sarcoma; Recomb l-AGN, recombinant l-Asparaginase; CSF, colony-stimulating factor; CT, chemotherapy; ALL, acute lymphoblastic leukemia; PIP, pediatric investigation plan; NOV, November; DEC, December; RMS, rhabdomyosarkoma; Refused W, refused waiver.