Figure 6.

Cognitive impairments after long-term hypoperfusion (N=14 per group). Spatial working memory was impaired in hypoperfused mice, performing significantly less novel arm entries and significantly greater revisiting errors (A). Analysis of spatial reference learning and memory in the water maze identified a significant deficit in latency and path length (B) in the hidden platform task. Data are shown from the first probe trial to examine long-term spatial reference memory (C and D). Sham mice showed better-than-chance performance when compared with hypoperfused mice who did not reach chance performance. Hypoperfused mice also conducted significantly less platform crossings (D) and spent less time (D) in the target area than sham mice. *P<0.05.