Figure 4.
Preconditioning effects of cortical lesions. Edema-corrected infarct volumes at 24 hours after ischemia onset were reduced in rats subjected to prior cryogenic lesions (CL), with no effect of sham procedures. Comparable results were obtained under halothane and isoflurane anesthesia. Volumetric assessment of the ischemic territory (cerebral blood flow (CBF)⩽30 mL/100 g per minute) at 3 hours after occlusion, using an autoradiographic [14C]-iodoantipyrine method, predicted final histopathologic outcomes in the respective groups. *P⩽0.05 versus Naive groups.