Table 1. Study characteristics.
Publications, no. | 27 |
Experiments, no. | 55 |
Median number of animals per experiment, median (IQR) | 10 (7–15) |
Species, no. (%) of experiments | |
Rabbit | 19 (35) |
Dog | 17 (31) |
Monkey | 8 (15) |
Rat | 6 (11) |
Mouse | 4 (7) |
Pig | 1 (2) |
Sex, no. (%) of experiments | |
Male | 14 (25) |
Female | — |
Mixed | 12 (22) |
Not stated | 29 (53) |
SAH induction, no. (%) of experiments | |
Autologous blood injection | 40 (73) |
Donor blood injection | 3 (5) |
Autologous blood clot placement | 8 (15) |
Blood injection not specified | 3 (5) |
Endovascular perforation | 1 (2) |
Outcomes assessed, no. (%) of experiments | |
Case fatality | 8 (15) |
Neurobehavioral score | — |
Vasospasm | 43 (78) |
Cerebral blood flow | 4 (7) |
Timing of medication administration, no. (%) of experiments | |
Before SAH | 12 (22) |
At induction of SAH | 19 (35) |
Within 60 minutes after SAH | 13 (24) |
61 minutes until 1 day after SAH | 7 (13) |
More than 1 day after SAH | 4 (7) |
Timing of outcome assessment (days; median (IQR)) | |
Case fatality | 7 (6-7) |
Neurobehavioral score | N/A |
Study quality (median (IQR)) | 4 (3–5) |
Abbreviations: IQR, interquartile range; no. number; SAH, subarachnoid hemorrhage.