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. 2015 May 13;35(10):1593–1600. doi: 10.1038/jcbfm.2015.83

Figure 2.

Figure 2

Effects of Kv7-acting drugs and dopamine receptor antagonists on oxygen and glucose deprivation (OGD)-induced toxicity measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining. (A-C) Effects on TTC staining exerted by increasing concentrations of retigabine (A), ICA27243 (B), and linopirdine (C) in OGD-exposed brain slices, as indicated. Data from vehicle-treated slices are represented by white columns. (D) Effects on TTC staining of 1 μmol/L retigabine alone (white columns) or coincubated with 10 μmol/L linopirdine (light gray columns). (E and F) Effects on TTC staining in OGD-exposed slices of 10 μmol/L SCH23390 (E) and 1 μmol/L metoclopramide (F) used alone and coincubated with 30 μmol/L linopirdine. Data from vehicle-treated slices are represented by white columns. All data are expressed as percentage of normal artificial cerebrospinal fluid (aCSF)-incubated slices (control, black columns). Each bar represents the mean±s.e.m. of 4 to 7 slices from 4 to 5 rats. *P<0.05.