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. 2015 May 13;35(10):1640–1647. doi: 10.1038/jcbfm.2015.99

Figure 5.

Figure 5

BDNF-TrkB blockade attenuates chaetocin-induced protection in oxygen glucose deprivation (OGD). Blockade of BDNF-TrkB with K252a and SUV39H1 and G9a inhibition with chaetocin. Evaluation of cell death by lactate dehydrogenase (LDH) measurement. Included are 10 independent experiments, consisting of 3 wells/condition each. A two-way analysis of variance (ANOVA) was conducted that examined the effect of OGD and treatment on cell survival. There was a significant interaction between effects of OGD and treatment, F(3,72)=3.546 with P=0.019 for interaction. A Tukey post hoc analysis was performed. Selected significant effects are indicated in the figure *P<0.05. BDNF, brain-derived neurotrophic factor.