Table 2. Injury characterization.
|
7 Days (before treatment) |
21 Days (after treatment) |
||||
|---|---|---|---|---|---|
| Volume [mm3] | All subjects (N=20) | L-655,708 (N=10) | Placebo (N=10) | L-655,708 (N=10) | Placebo (N=10) |
| Total stroke | 68±11 | 77±19 | 58±12 | 52±18 | 60±18 |
| Necrotic core | 6±1 | 6±1 | 5±1 | 2.1±0.3 | 4±1 |
| Periinfarct | 62±11 | 71±19 | 53±11 | 50±18 | 56±18 |
| Skilled reaching | All subjects (N=20) | L-655,708 (N=11) | Placebo (N=9) | L-655,708 (N=11) | Placebo (N=9) |
| %Prestroke ability | 34±2 | 37±3 | 31±3 | 62±4 | 37±3 |
Sham-operated animals: 101%±5% at 7 and 107%±4% at 21 days after phosphate-buffered saline injection (N=7).
The regional volumes and skilled reaching performance before treatment (i.e., 1 week after stroke) and after 2 weeks of treatment (i.e., 3 weeks after stroke). The volumes of interest are quoted for all animals with stroke (N=21, column two); L-655,708-treated animals with stroke (N=11, columns three and five); and animals with stroke given a placebo (N=10, columns four and six). The total stroke volume comprises the necrotic core and the perilesional tissue. Skilled reaching is expressed in percentage of prestroke performance. Errors are in ±s.e.m.