Table 2. Brain regions with significant contributions to the Parkinson's disease-related cognitive pattern derived from the Groningen data (PDCPGR).
Brain regiona | Coordinatesb | Zmaxc | ||
---|---|---|---|---|
x | y | z | ||
Network-related decreases (negative voxel weights) | ||||
Thalamus (mediodorsal nucleus) | 0 | −16 | 2 | 4.35 |
Caudate nucleus | −10 | 8 | 6 | 3.32 |
Supplementary motor area (rostral, BA 6) | 2 | 14 | 50 | 4.11 |
Superior parietal association cortex, BA 5 | 0 | −38 | 54 | 3.77 |
Inferior parietal cortex, BA 7, 40 | 46 | −54 | 60 | 3.54 |
Posterior cingulate cortex, BA 29 | 0 | −52 | 6 | 3.64 |
BA 23 | −2 | −24 | 28 | 3.19 |
Network-related increases (positive voxel weights) | ||||
Cerebellum, lobule VI, Crus I | 28 | −52 | −38 | 2.49 |
Anterior cingulate, BA 32, right | 20 | 42 | −2 | 2.59 |
BA 32, left | −18 | 38 | 16 | 2.55 |
Abbreviation: BA, Brodmann area.
All brain regions are significant at Z>2.44 (P<0.01) and stable on bootstrap resampling (P<0.01).
Montreal Neurological Institute standard space.
Maximum voxel weights in Z-scores.