Figure 3.

Lack of calcium diminishes the NADH overshoot. The model simulations were performed by coupling the activation with an increase in cytosolic calcium up to a maximal value of 0.4 μmol/L (bold curves) and 0.2 μmol/L (dotted curves). (A) NADH transients elicited by a 10-second electric stimulus with concomitant increase in cytosolic calcium concentration. (B and C) Cytosolic and mitochondrial calcium transients. (D and E) Cytosolic and mitochondrial ATP transients. (F) Relative oxygen consumption rate. For comparison, the small insert in A shows the experimental data from Kann et al.⁴