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. 2015 Apr 29;35(9):1515–1522. doi: 10.1038/jcbfm.2015.75

Figure 1.

Figure 1

20-Hydroxyeicosatetraenoic acid (20-HETE) levels in outcome groups. Mean (A) and maximum (B) 20-HETE levels in cerebrospinal fluid (CSF) from patients with aneurysmal subarachnoid hemorrhage (aSAH) are compared in outcome groups. Acute outcomes (solid bars) included the presence or absence of clinical neurologic deterioration (CND) and/or delayed cerebral ischemia (DCI) up to 14 days after the hemorrhage. Long-term outcomes (stripped bars) were determined by global functional recovery at 3 and 12 months using the Modified Rankin Scale (MRS) and were dichotomized into favorable (MRS 0 to 2) and unfavorable (MRS 3 to 6) groups. The mean and maximum 20-HETE CSF levels for each patient (n=269) were calculated and were used to compare the mean±standard error of the mean of the cytochrome P450 (CYP)-eicosanoid levels in outcome groups using t-test (with Levene's test for equality of variances). Depicted P values are adjusted for age, sex, race, and either Fisher grade (for acute outcomes) or Hunt and Hess score (for long-term outcomes). Statistical significance established at *P<0.05 and **P<0.0167 (correction for multiple comparisons).