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. 2015 May 13;35(9):1537–1546. doi: 10.1038/jcbfm.2015.91

Figure 2.

Figure 2

Selective blockade of isoproterenol-induced dilation in superior cerebellar arteries (SCA). (A) Representative recording of outer diameter of an isolated, pressurized (80 mm Hg) rat SCA. The artery was initially exposed to increasing half-log concentrations (▾) of isoproterenol (ISO). After repeated washes, the artery was incubated with 30 nmol/L CGP20712 for 10 minutes before repeating the ISO concentration response. (B) ISO concentration response in the presence of the β1AR-selective blocker CGP20712 (30 nmol/L, 100 nmol/L; n=5 to 8). (C) ISO concentration response in the presence of the β2AR selective blocker ICI118551 (10 nmol/L, 30 nmol/L; n=6 to 8). *Significant difference from Control, P<0.05.