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. 2015 May 13;35(9):1537–1546. doi: 10.1038/jcbfm.2015.91

Figure 4.

Figure 4

Norepinephrine-induced dilation of superior cerebellar arteries (SCA) ex vivo and middle cerebral arteries (MCA) in vivo. (A) Outer diameter measurements of isolated, pressurized (80 mm Hg) SCA in response to increasing concentrations of norepinephrine (NE) in the presence of β2-adrenergic receptor (AR) blocker ICI118551 (10 nmol/L), β1AR blocker CGP20712 (30 nmol/L), and the αAR blocker phentolamine (1 μmol/L), n=5 each. (B) Concentration response of MCA branches to norepinephrine (NE) alone and with 5-minute pretreatment and coadministration of 30 μmol/L CGP20712 in cranial window, n=7 each. *Significant difference from control, P<0.05.