Table 6.
Evaluation of the protective effect of the plants extracts on the biochemical parameters of liver in CCl4-induced hepatic damage in mice
| Control | CCl4 control | F. indica | Z hamiense | C. procera | S. imbricata | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 5 mg/kg | 10 mg/kg | 250 mg/kg | 500 mg/kg | 100 mg/kg | 200 mg/kg | 250mg/kg | 500mg/kg | |||
| ALT (U/L) | 290.1 ± 54.0 | 1736.7 ± 161.2a | 2166.7 ± 157.8b | 1064.0 ± 264.9c | 1416.7 ± 105.8 | 950.3 ± 84.4 | 1054.3 ± 117.5c | 801.7 ± 76.0c | 1135.0 ± 127.9c | 476.7 ± 151.0c |
| AST(U/L) | 850.0 ± 63.2 | 1736.7 ± 215.1a | 1310.0 ± 181.5b | 926.2 ± 258.6c | 756.7 ± 128.6c | 783.3 ± 80.1c | 787.8 ± 69.6c | 922.7 ± 65.4c | 647.5 ± 62.8c | 530.0 ± 120.8c |
| ALP(U/L) | 180.0 ± 20.3 | 150.2 ± 55.7 | 125.0 ± 22.5 | 124.3 ± 17.4 | 106.7 ± 24.0 | 113.3 ± 29.1 | 51.8 ± 4.7 | 59.5 ± 6.1 c | 110.0 ± 14.7 | 63.3 ± 8.8 |
| CAT kU/g protein | 462.0 ± 21.1 | 241.3 ± 11.4a | 307.2 ± 9.2c | 392.200 ± 9.4c | 225.1 ± 10.5 | 259.1 ± 5.1 | 324.7 ± 25.8b | 335.0 ± 25.0c | 356.2 ± 24.1c | 374.9 ± 10.7c |
| GSH-Px U/g protein | 1.3 ± 0.1 | 0.85 ± 0.06a | 1.1 ± 0.2 | 1.2 ± 0.2 | 0.72 ± 0.1 | 0.94 ± 0.2 | 1.4 ± 0.06 | 1.4 ± 0.06 | 0.91 ± 0.06 | 1.39 ± 0.19b |
| SOD μg/g protein | 34.6 ± 2.9 | 22.0 ± 2.4a | 26.7 ± 1.8 | 32.9 ± 1.6c | 21.1 ± 1.7 | 23.6 ± 1.5 | 22.7 ± 1.2 | 31.5 ± 1.1b | 24.8 ± 0.5 | 26.4 ± 1.3 |
| TBARS (nmol/g prot.) | 0.049 ± 0.02 | 0.54 ± 0.20a | 0.12 ± 0.09c | 0.085 ± 0.05c | 0.42 ± 0.2 | 0.36 ± 0.4 | 0.14 ± 0.07c | 0.06 ± 0.01c | 0.11 ± 0.05c | 0.071 ± 0.02c |
aSignificant difference (p < 0.01) compared to control group; bSignificant difference (p < 0.05) compared to CCl4 treated group; cSignificant difference (p < 0.01) compared to CCl4 treated group