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. Author manuscript; available in PMC: 2016 Aug 21.
Published in final edited form as: Brain Inform Health (2015). 2015 Aug 21;9250:115–124. doi: 10.1007/978-3-319-23344-4_12

Fig. 1.

Fig. 1

Overview of the proposed Imaging Genetic Enrichment Analysis (IGEA) framework. (A) Perform SNP-level GWAS of brain wide imaging measures. (B) Map SNP-level GWAS findings to gene-level. (C) Construct gene-ROI expression matrix from AHBA data. (D) Construct GS-BC modules by performing 2D hierarchical clustering, and filter out non-significant 2D clusters. (E) Perform IGEA by mapping gene-level GWAS findings to identified GS-BC modules. (F) For each enriched GS-BC module, examine the GS using GO terms, KEGG pathways, and OMIM disease databases, and map the BC to the brain.