Table 4. Pharmacokinetics parameters in the animal model and humans.

Product		Rabbit Pharmacokinetic			Human Pharmacokinetic
		Zidovudine	Lamivudine	Stavudine	Zidovudine	Lamivudine	Stavudine
Cmax	µg/mL	12.17	3.31	3.15	2.12	0.94	0.73
Tmax	h	0.75	1.00	0.33	0.33	1.00	0.50
T1/2	h	1.12	0.95	1.00	0.72	2.68	1.37
AUC (0-t)	h*µg/mL	25.17	6.87	4.38	2.16	3.51	1.67
AUC(0-∞)	h*µg/mL	26.00	6.99	4.90	2.16	3.51	1.67
AUMC (0-t)	µg-h*h/mL	41.34	11.62	4.97	3.02	10.41	3.02
AUMC(0-∞)	µg-h*h/mL	47.71	12.53	7.10	3.02	10.41	3.02

^C_max= maximum concentration

^T_max = time required to reach the maximal concentration

AUC= area under the curve in time

AUMC= Area under the first moment curve