. 2015 Jun;240(6):774–786. doi: 10.1177/1535370215579168

Table 2.

NPM in post-mitotic neurons

In vivo model	In vitro model	Impact on cell viability	Effect on NPM	Reference
Spinal cord injury
Mice injected with recombinant human G-CSF following hemisection of the right hemicord	G-CSF treated neurons isolated from the spinal cords	Neuroprotection and locomoter recovery following G-CSF treatment	In vivo upregulation of NPM expression	82
	G-CSF treated neurons isolated from the spinal cords		NPM inhibition partially blocked G-CSF neuroprotection	82
Excitotoxicity
PS1 M146V mutant transgenic mice	Glutamate-induced excitiotoxicity of cortical neuronal cultures	Decreased survival rate	Decreased expression of NPM mRNA	84
NMDA-induced excitiotoxicity in the cerebral cortex of mice	PC12 cells	Protection against SIAH1-GAPDH induced death	NPM disrupts SIAH1-GAPDH complex	85
NMDA-induced excitiotoxicity in the cerebral cortex of mice	NMDA-treated primary cortical neurons	Protection against SIAH1-GAPDH induced death	Overexpression in cortical neurons and mice inhibited NMDA-induced toxicity by inhibiting SIAH1	85
Kainic acid (KA)-induced excitiotoxicity in rats	KA-treated primary cortical neurons and SH-SY5Y cells	Decreased NPM shows increased p53 levels in KA-treated SH-SY5Y cells	Downregulation of NPM protein in degenerating neurons of the hippocampal CA1 region of KA-treated rats and KA-treated primary cortical neurons	86
Kainic acid (KA)-induced excitiotoxicity in rats	NE-4C cells	Apoptosis following NPM downregulation is p53-independent		86
Nucleolar Stress
	Cultured cortical neurons treated with camptothecin	Reduced rRNA transcription and p53-mediated apoptosis	Nucleoplasmic relocalization from nucleoli	111
TIF-IA knockout in neural progenitors and hippocampal neurons		Impaired nucleolar activity and increased p53 levels	Nucleoplasmic relocalization from nucleoli	112
		Rapid apoptosis in neural progenitors
		Prolonged degeneration in the hippocampus
Post-mortem brain sections of PD patients		Nucleolar damage in human PD brains	Nucleoplasmic relocalization from nucleoli	113
TIF-IA knockout in dopaminergic neurons of mice		TIF-IA knockout results in parkinsonism in mice
Mice injected with MPTP		Increased p53 levels
		Downregulation of mTOR activity
TIF-IA knockout in medium spiny neurons of R6/2 mice		Late progressive striatal degeneration	Nucleoplasmic relocalization from nucleoli	114
TIF-IA knockout in medium spiny neurons of R6/2 mice		p53 prolongs survival through PTEN upregulation, inhibition of mTOR signaling and activation of autophagy	Nucleoplasmic relocalization from nucleoli	114