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. 2015 Nov 5;56(12):7214–7223. doi: 10.1167/iovs.15-17107

Figure 2.

Figure 2

Transplantation of HSPC leads to ocular cystine and corneal cystine crystal clearance. (a) Cystine levels measured in the whole eye were significantly reduced in the HSPC-transplanted mice, Low and High, compared to the Ctns−/− controls. Error bars: SEM (*P < 0.05, **P < 0.005). (b) Lateral cornea IVCM representations of Ctns−/− controls and Low and High HSPC-transplanted mice. Abundant cystine crystals were observed in the whole cornea in Ctns−/− mice in contrast to Ctns−/− with high level of engraftment where residual crystals can be seen only in the posterior stroma. (c) Surface crystal quantification within each layer of the full IVCM cornea scans from both eyes of Ctns−/− controls and transplanted (Low and High) mice. Transplantation of HSPC with high level of engraftment prevents almost completely cystine crystal formation within the superior layers of the cornea (epithelium to middle stroma). The mice with low level of engraftment exhibit significant but more modest crystal reduction. Error bars: SEM (*P < 0.05, **P < 0.005).