Table 3. SNP rs3821949 and rs12532 within MSX1 gene associated with the risk of congenital heart diseases in Chinese populations.
Title | Pearson Chi-square | Pearson’s R | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Genotyped SNP | Disease Type | Statistical Types | Value | Min count a | df | Asymp. Sig. (2-sided) | Value | Asymp. Std. error b | Approx. T c | Approx. Sig |
rs3821949 | CHD-Control | Genotype | 7.974 | 31.29 | 2 | 0.019 | -0.098 | 0.038 | -2.606 | 0.009 d |
Allele | 9.231 | 125.14 | 1 | 0.002 | -0.081 | 0.027 | -3.046 | 0.002 d | ||
VSD-Control | Genotype | 4.425 | 12.61 | 2 | 0.109 | -0.086 | 0.045 | -1.976 | 0.049 d | |
Allele | 5.376 | 50.18 | 1 | 0.020 | -0.071 | 0.032 | -2.322 | 0.020 d | ||
ASD-Control | Genotype | 8.029 | 10.76 | 2 | 0.018 | -0.118 | 0.047 | -2.661 | 0.008 d | |
Allele | 9.657 | 42.84 | 1 | 0.002 | -0.098 | 0.034 | -3.119 | 0.002 d | ||
rs12532 | CHD-Control | Genotype | 6.187 | 40.71 | 2 | 0.045 | 0.069 | 0.038 | 1.825 | 0.068 d |
Allele | 3.079 | 234.86 | 1 | 0.079 | 0.047 | 0.027 | 1.755 | 0.079 d | ||
VSD-Control | Genotype | 6.509 | 16.00 | 2 | 0.039 | 0.110 | 0.042 | 2.536 | 0.012 d | |
Allele | 5.627 | 100.12 | 1 | 0.018 | 0.073 | 0.030 | 2.376 | 0.018 d | ||
ASD-Control | Genotype | 0.972 | 14.14 | 2 | 0.615 | 0.000 | 0.043 | 0.001 | 0.999 d | |
Allele | 0.000 | 88.01 | 1 | 0.999 | 0.000 | 0.031 | 0.001 | 0.999 d |
a: The minimum expected count
b: Not assuming the null hypothesis
c: Using the asymptotic standard error assuming the null hypothesis
d: Based on normal approximation